Just before using BRIVIACT, tell your healthcare provider about all your medical disorders, including in case you:
enasidenib will enhance the degree or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Enasidenib (a weak CYP2C19 inhibitor) may well enhance systemic exposure of sensitive CYP2C19 substrates. Keep track of and change dose of substrate as clinically indicated.
Prevent coadministration of sensitive CYP3A4 substrates with ivosidenib or exchange with alternate therapies. If coadministration is unavoidable, observe sufferers for loss of therapeutic effect of such medication.
Dihydrocodeine is an opioid analgesic agent employed for the administration of ache severe sufficient to need an opioid analgesic and for which choice therapies are insufficient.
cenobamate will enhance the degree or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Intently. Consider a dose reduction of CYP2C19 substrates, as clinically suitable, when utilized concomitantly with cenobamate.
darifenacin will raise the degree or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
buprenorphine subdermal implant and diazepam both of those boost sedation. Stay away from or Use Alternate Drug. Restrict use to people for whom option cure solutions are insufficient
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fosphenytoin will decrease the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep here an eye on.
Thanks to isolated stories of neutropenia and jaundice, periodic blood counts and liver purpose exams are highly recommended throughout prolonged-time period therapy
Prevent or substitute One more drug for these medications when doable. Appraise for loss of therapeutic impact if medication needs to be coadministered. Regulate dose In accordance with prescribing details if required.
Reserve concomitant prescribing of those medication in individuals for whom other therapy alternatives are insufficient. Restrict dosages and durations towards the minimum amount essential. Observe carefully for signs of respiratory depression and sedation.
Contraindications: APTIOM is contraindicated in sufferers having a hypersensitivity to eslicarbazepine acetate or oxcarbazepine.
diazepam will increase toxicity of oliceridine by Other (see remark). Modify Therapy/Keep an eye on Closely. Remark: Anticholinergic medicines may possibly improve hazard of urinary retention and/or extreme constipation, which may result in paralytic ileus.